Ish Kumar

Associate Professor of Chemistry

School of Natural Sciences


Research Interests

  • Bioorganic and Medicinal chemistry: Virtual Screening and evaluation of non-covalent inhibitors of clinically important enzyme targets: We are interested in how enzyme structure determines function, with a focus on novel inhibitor discovery using a combination of computational chemistry, enzyme kinetics and molecular designing.
  • Application of Biocatalysis in Organic Synthesis: Biocatalysis in the preparation of enatiomerically pure pharmaceuticals, their intermediates and fine chemicals by following approaches such as microbial screening, enzyme screening, substrate-structure screening and solvent screening.

Selected Publications:
L Dzhekieva, Ish Kumar and R. F. Pratt: Inhibition of Bacterial DD-Peptidases (Penicillin-Binding Proteins) in Membranes and in Vivo by Peptidoglycan-Mimetic Boronic Acids, Biochemistry 51, 2804-2811 (2012).
Mihaela D. Leonida and Ish Kumar: Microfluidics: from Engineering to Life Sciences, Current Nanoscience, 8, 458-473 (2012).
D. Dana, T. K. Das, Ish Kumar, A. D. Morinigo, K. J. Mark, D. Ramai, E. J. Chang, T.T. Talele and Sanjai Kumar: Design, Synthesis, and Evaluation of 2-(arylsulfonyl)oxiranes as Cell-permeable Covalent Inhibitors of Protein Tyrosine Phosphatases, Chemical Biology & Drug Design, 80 (4), 489-499 (2012) (cover page article of the issue).
S.A. Adediran, Ish Kumar, Rajesh Nagarajan, Eric Sauvage, and R. F. Pratt: Kinetics of Reaction of the Actinomadura R39 DD- Peptidase with Specific Substrates, Biochemistry 50, 376-387 (2011).
S.A. Adediran, Ish Kumar, Rajesh Nagarajan, E. Sauvage, and R. F. Pratt: Kinetics of Reaction of the Actinomadura R39 DD- Peptidase with Specific Substrates, Supportive Information: http://pubs.acs.org/
Ish Kumar, Helen R Josephine, R. F. Pratt: Reactions of Peptidoglycan-Mimetic beta-Lactams with Penicillin-Binding Proteins in Vivo and in Membranes. ACS Chem. Biol. 2, 620-624 (2007).
Puja Shahi, Ritu Sharma, Shefali Sanger, Ish Kumar, Ravinder S. Jolly: Amyloid fibril formation via longitudinal growth of oligomers Biochemistry 46(43),7365-7373 (2007).
S.A. Adediran, Ish Kumar and R.F.Pratt: Deacylation Transition States of Bacterial DD-Peptidases Biochemistry 45(43), 13074-13082 (2006).
Puja Shahi, Ish Kumar, Ritu Sharma, Shefali Sanger and Ravinder S. Jolly: Characterization of Periplasmic Long chain Acyl-CoA thio esterase from Alcaligen faecalis FEBS Journal, 273, 2374-87 (2006).
Ish Kumar and R.F. Pratt: Transpeptidation of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase: the structural basis of acyl acceptor specificity Biochemistry 44 (30), 9961-9970 (2005).
Ish Kumar and R.F. Pratt: Transpeptidation of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase II: Characterization of a Chromogenic Substrate and Acyl Acceptor Design. Biochemistry 44 (30), 9971-9979 (2005).
Helen R Josephine, Ish Kumar, R.F. Pratt: The perfect pencillin? Inhibition of a bacterial DD-peptidase by peptidoglycan-mimetic â-lactams. J.Am.Chem.Soc 126 (26), 8122-23 (2004).
B. N Singh, J. J. Lucas, G. R. Hayes, Ish Kumar, D.H. Beach, Marcel Frajbalt, R. O. Gilbert, U. Sommer, C.E Costello: Trichomonas foetus Parasite Induces Apoptotic Cell Death in Bovine Host Cells in Vitro Infection and Immunity, 72(7), 4151-4158 (2004).
Ish Kumar and Ravinder S. Jolly: A Thioesterase for Chemoselective Hydrolysis of S-Acyl Sulfanylalkanoates Org. Lett. 3 (2), 283-285 (2001.
Ish Kumar, Kavita Manju and Ravinder S. Jolly: A New Biocatalyst for the Preparation of Enantiomerically Pure 2-arylpropanoic acids Tetrahedron Asymmetry, 12(10), 1431-34, (2001).
Ish Kumar and Ravinder S. Jolly: The effect of the á-methyl substituent on chemoselectivity in esterase catalyzed hydrolysis of S-acetylsulfanylalkanoates. Org. Lett. 1(2), 207-209 (1999).

Patents:
Ravinder S. Jolly, Rakesh M. Vohra and Ish Kumar: A process for the preparation of enantiomerically pure D- (-)alpha– 3-acetylthio-2-methylpropanoic acid. Indian Patent Application, filed in 1999 (1287/DEL/99); published in gazette on Dec 6th 2003 (Indian Patent No: 191586)

Links of interest:

American Chemical Society
Auto dock
Small molecule database


Short Abstract

University College

School of Natural Sciences
1000 River Road, (H-DH4-03)
Teaneck, NJ 07666 


Courses I teach:

CHEM 6752 Drug Design and Discovery
CHEM 2211 Inorganic Chemistry I
CHEM 3314 Inorganic Chemistry II
CHEM7713 Structural Inorganic Chemistry
CHEM 1203 General Chemistry Lab I
CHEM 1204 General Chemistry Lab II