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Chemistry and Pharmaceutical Science - Dr. Avaltroni

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Education:

Ph.D., Princeton University, 2003
M.A., Princeton University, 2001
B.S., Fairleigh Dickinson University, 1999

 

Courses taught at FDU:

General Chemistry
Introduction to Forensic Science
Physical Chemistry

 

Research interests:

Because Americans are living longer and leading increasingly active lifestyles, orthopedic joint replacements are becoming a common surgical procedure. While hundreds of thousands of hip and knee replacements are performed annually, few patients are aware of the potential problems and risks that this surgical procedure can entail. Over 10% of implants fail within the first year after surgery, and serious post-operative infection risk is becoming a side effect of increasing frequency. In fact, post operative “staph” (Staphylococcus aureus) infections were observed in nearly 45% of patients who underwent orthopedic procedures during the past year. Many of these bacterial infections are resistant to common antibiotics, and the result has been an observed 35% increase in post-surgical mortality.

Our current research has developed methods to improve integration of implants into the body, potentially offering a significant reduction in failure rate, post surgical side effects and infection risk. Through the use of surface chemistry, implants can be coated with materials which perfectly integrate the device into the surrounding bone and tissue, creating a “perfect fit” and eliminating the potential side effects that result from poor osteointegration (attachment of the existing bone to the implant surface). Recent in vivo testing has showed a 300% improvement of implant strength and integration over the current industry standard following surgical implantation within a rabbit model. Continued research in this area is being conducted to develop an implant that exhibits this increased strength in conjunction with a resistance to bacterial infection.

 

Publications and patents:

1. Schwartz, Jeffrey (Princeton, NJ); Avaltroni, Michael J. (Staten Island, NY); Gawalt, Ellen S. (Pittsburgh, PA) Devices with Multiple Surface Functionality. U.S. Patent 8,993,117, March 31, 2015

2. Schwartz, Jeffrey (Princeton, NJ); Avaltroni, Michael J. (Staten Island, NY); Midwood, Kim S. (Princeton, NJ), Schwarzbauer, Jean E. (Princeton, NJ), Gawalt, Ellen S (Pittsburgh, PA) Enhanced Bonding Layers on Titanium Materials. U.S. Patent 8,758,899, January 24, 2014

3. Schwartz, Jeffrey (Princeton, NJ); Avaltroni, Michael J. (Staten Island, NY); Midwood, Kim S. (Princeton, NJ), Schwarzbauer, Jean E. (Princeton, NJ), Enhanced Bonding Layers on Titanium Materials. U.S. Patent 8,092,585, January 10, 2012

4. Schwartz, Jeffrey (Princeton, NJ); Danahy, Michael P. (Lewiston, ME); Avaltroni, Michael J. (Staten Island, NY) and Guo, Jing (Sunnyvale, CA), Enhanced Bonding Layers on Native Oxide Surfaces. U.S. Patent 7,931,943, April 26, 2011

5. Schwartz, Jeffrey (Princeton, NJ); Avaltroni, Michael J. (Staten Island, NY); Danahy, Michael P., Carrier Applied Coating Layers. U.S. Patent 7,879,456, February 1, 2011

6. Schwartz, Jeffrey (Princeton, NJ); Avaltroni, Michael J. (Staten Island, NY); Midwood, Kim S. (Princeton, NJ), Schwarzbauer, Jean E. (Princeton, NJ), Enhanced Bonding Layers on Titanium Materials. U.S. Patent 7,815,963, October 19, 2010

7. Avaltroni, M.J.(Staten Island, NY); Bruner, E.L. (San Diego, CA); Hanson, E.(San Diego, CA); "Thin Films", United States Patent 7,691,478, April 6, 2010

8. Schwartz, Jeffrey (Princeton, NJ); valtroni, Michael J. (Staten Island, NY); Midwood, Kim S. (Princeton, NJ), Schwarzbauer, Jean E. (Princeton, NJ), Enhanced Bonding Layers on Titanium Materials. U.S. Patent 7,569,285, August 4, 2009

9. Schwartz, Jeffrey (Princeton, NJ); Danahy, Michael P. (Lewiston, ME); Avaltroni, Michael J. (Staten Island, NY) and Guo, Jing (Sunnyvale, CA), Enhanced Bonding Layers on Native Oxide Surfaces. U.S. Patent 7,507,483, March 24, 2009

10. Schwartz; Jeffrey (Princeton, NJ), Avaltroni; Michael J. (Staten Island, NY), Danahy; Michael P. (Princeton, NJ), Silverman; Brett M. (Princeton, NJ), Carrier Applied Coating Layers. U.S. Patent 7,396,594, July 8, 2008

11. Shannon, Fintan J.; Cottrell, Jocelyn M., Deng, Xiang-Hua, Doty, Steven B.; Warren, Russell F.; Wright, Timothy M.; Crowder, Katherine, N.; Avaltroni, Michael J.; Schwartz, Jeffrey; "A Novel Surface Treatment for Porous Metal Implants That Improves The Rate of Bony Ingrowth" Journal of Biomedical Materials Research A. Sept. 15, 2008; 86(4):857-864

12. Danahy, M. P.; Avaltroni, M. J.; Midwood, K. S.; Schwarzbauer, J. E., Schwartz, J. "Self Assembled Monolayers of ????Diphosphonic Acids on Ti Enable Complete of Spatially Controlled Surface Derivitization." Langmuir, 2004, 20, 5333-5337

13. Schwartz, J.; Avaltroni, M. J.; Danahy, M. P.; Silverman, B. M.; Hanson, E. L. ; Schwarzbauer, J. E.; Midwood, K.; Gawalt, E. S. "Cell Attachment and Spreading on Metal Implant Materials." Materials Science and Engineering C, 2003, 23, 395-400

14. Gawalt, E. S.; Avaltroni, M. J.; Danahy, M. P.; Silverman, B. M.; Hanson, E. L.; Midwood, K. S.; Schwarzbauer, J. E.; Schwartz, J. "Bonding Organics to Ti Alloys: Facilitating Human Osteoblast Attachment and Spreading on Surgical Implant Materials." Langmuir, 2003, 19, 200-204

15. Schwartz, J.; Gawalt, E.; Avaltroni, M. "Enhanced bonding of phosphoric and phosphonic acids to oxidized subtrates"; United States Patent #6,645,644, November 11, 2003

16. Gawalt, E. S.; Avaltroni, M. J.; Koch, N.; Schwartz, J. "Self Assembly and Bonding of Alkanephosphonic Acids on the Native Oxide Surface of Titanium." Langmuir, 2001, 17, 5736-5740

 

Patents pending and other intellectual property:

1. Avaltroni, Michael J.; Bruner, Eric L.; Hanson, Eric L.; "Organophosphate Adhesion Promoters" U.S. Patent, Submitted 2006

2. Schwartz, J; Avaltroni, M.J.; Danahy, Michael P.; Silverman, Brett M.; "Carrier Applied Coating Layers"; 2005, United States Patent 10/876,294

3. Schwartz, J.; Avaltroni, M.; Carolus, M.; Hanson, E.; Schwarzbauer, J.; Midwood, K.; Danahy, M. "Enhanced bonding layers on native oxide surfaces"; 2004, United States Patent 10/405,557

4. Schwartz, J.; Danahy, M.; Avaltroni, M.; Midwood, K.; Schwarzbauer, J.; Carolus, M.; Gawalt, E. "Enhanced bonding layers on titanium materials"; 2004, United States Patent 10/179,743

 

Scholarly and invited presentations:

1. Keynote Presentation, Independent College Fund of New Jersey, Undergraduate Research Symposium, March 24, 2014

2. Middle States College Board Regional Forum, Atlantic City, NJ, Developing Partnerships Between High Schools and Colleges through Enrichment Activities for High School Students, February 14, 2008

3. Oak Ridge National Laboratory, Oak Ridge, TN, Surface Modification As A Technique For Improving Biomedical Engineering, November, 2007

4. Techniques to Improve Orthopedic Implant Fixation, Telemedicine and Technology Research Center, U.S. Military Materiel Command, Fort Detrick, MD, May 2005

5. Utilizing SAMP Surfaces as a Biologically Relevant Interface, Advanced Medical Technology Institute, Beth Israel Medical Center, May 2005

6. Surface Modification of Biologically Relevant Metals for Increased Osteointegration and Orthopedic Performance, Fairleigh Dickinson University, September 2005

7. Emerging Technologies Using SAMP Surfaces, Telemedicine and Technology Research Center, U.S. Military Materiel Command, Fort Detrick, MD, September 2005

8. Surface Modification of Titanium Materials to Facilitate Cell Attachment, Biomineralization and Interfacial Adhesion, Princeton University, Department of Chemistry, June 2003

9. Using Organometallic Surface Chemistry to Deliver Vancomycin to the Site of Orthopedic Infection, Princeton University, Department of Chemistry, June 2003

10. Using Titanium Self Assembled Monolayers to Create Surface Biocompatibility at the Bone-Implant Interface, Fairleigh Dickinson University, April 2003

 

Poster presentations:

1. Avaltroni, MJ, Rivkin, A, Rossi, B, Sandifer, C; Using Community Partnerships to Develop Co-Curricular Initiatives that Promote the Core Values of our School, American Association of Colleges of Pharmacy, July, 2015

2. Avaltroni, MJ, Rivkin, A, Rossi, B, Sandifer, C; Promoting Community Engagement and Advocacy Across the Pharmacy Curriculum, American Association of Colleges of Pharmacy, July 26, 2014

3. Rattinger GB, Rivkin A, Carbone A, Elk N, Giordano P, Kim D, Park T, Avaltroni M. Assessing P2-pharmacy students' ability to identify drug-related problems using different methods. Poster presentation at the AACP Annual Meeting, Grapevine, TX, July 2014.

4. Avaltroni, MJ, Rivkin, A, Rossi, B, Sandifer, C; Advancing Pharmacy Education Through a Series of Innovative Curricular and Co-Curricular Strategies, American Association of Colleges of Pharmacy, July 13, 2013

5. Rivkin A, Rattinger GB, Bishara MD, Hardeo S, Kim D, Pucci R, Spencer S, Westrich L, Rossi BA, Avaltroni MJ. Administration of high-stakes examinations in an active learning classroom. Poster presentation at the AACP Annual Meeting, Chicago, IL, July 2013.

6. Spencer S, Vansal S, Guo Y, Rattinger G, Westrich L, Avaltroni M, Rivkin A. Integration of iPads into a pharmacy classroom. Poster presentation at the AACP Annual Meeting, Chicago, IL, July 2013. 7. Avaltroni, MJ, Rivkin, A, Rossi, B, Sandifer, C; Building a New Pharmacy School Around a System of Five Core Tenets, American Association of Colleges of Pharmacy, July 12,2012

8. Italo, Daniela and Avaltroni, Michael J. – Developing the New Teflon, Fairleigh Dickinson University, Science Scholars Symposium, May, 2006

9. "Cell Attachment and Spreading on Implant Materials." American Chemical Society, Middle Atlantic Regional Meeting, June 2003, Princeton, NJ

10. "Surface Modification of Biomaterials: Interfacing Synthetics and Living Tissue." Princeton University Industrial Affiliates Partnership Meeting, June 2003, Princeton, NJ

11. "Cell Growth and Proliferation on Titanium Implant Materials." Princeton University Graduate Student Forum, March 2003, Princeton, NJ

12. "Osteoblast Growth on Novel Implant Materials." Microstructured Biomaterial Surfaces Symposium, June 2002, Strasbourg, France

 

Grant awards, major gifts and other funding:

1. Daniel and Martina Lewis Center for Healthcare Innovation and Technology, June 2015

2. Nektar Therapeutics Scholarship Fund, February 2015

3. Becton Dickinson Grant, Sterile Compounding Simulation Laboratory, June 2014

4. Baker Grifols Gift, Sterile Compounding Simulation Laboratory, May 2014

5. Daiichi Sankyo Endowed Lectureship, July 2012

6. BASF Summer Science Academy - From Molecules to Marketplace, June 2012

7. BASF Summer High School Science Academy, June 2011

8. Mustard Seed Foundation, May 2010

9. Schering Plough Corporation, Pharmacy School Start-Up Funding, September 2009

10.BASF Support Grant, Institute for the Enhancement of Teaching Science and Mathematics, July 2008

11.Martinson Family Foundation, Institute for the Enhancement of Teaching Science and Mathematics, November 2007

12.Pfizer Corporation, Summer Science Camp in Partnership with Morristown Science Academy, May 2008

13.National Science Foundation, Equipment Grant, May 2007

14.Schering Plough Corporation, Laboratory Renovation Grant, March 2006

15.Merck/AAAS Undergraduate Science Research Program, 2005

 

Awards and honors:

1. Mortar and Pestle Award, New Jersey Pharmacists Association, 2015

2. Best Places to Work in New Jersey, 2015

3. New Jersey Biz Magazine 40 Under 40, 2013

4. American Heart Association, Fit Friendly Workplace, 2013-present

5. Faculty Representative, FDU Now Fundraising Campaign Celebration, 2011

6. Presidential Citation, Fairleigh Dickinson University, 2009

7. Teacher of the Year Award, FDU Student Government, 2008

8. Invited Faculty Presenter, FDU Now Launch Event, 2007

9. Wyeth-Ayerst Third Year Seminar Award, 2002

10. Pickering Award for Excellence in Teaching, 2000

11. Dr. David Hart Award For Achievement in Chemistry, 1999

12. Faculty Service Award In Chemistry, 1999

13. Who’s Who Among American College Students, 1999

14. ACS Polymer Education Award for Organic Chemistry, 1997

15. CRC Press Achievement Award in Chemistry, 1996

Contact:

Dr. Michael Avaltroni
Dean, Becton College School of Pharmacy
Tel: 973-443-8782
mavaltro@fdu.edu

Department of Chemistry and Pharmaceutical Science
Fairleigh Dickinson University
285 Madison Ave - M-SB1-01
Madison, NJ 07940


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