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Chemistry and Pharmaceutical Science - Dr. Anderle

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Courses Taught at FDU:

Undergraduate
Physical Chemistry I Lecture
Physical Chemistry Laboratory I and II
Analytical Chemistry
Organic Chemistry Laboratory I and II
Foods Lecture & Laboratory
Chemistry of the Crime Scene

Graduate
Special Topics in Computational Chemistry

 

Research Interests: 

Computational Studies of Protein Structure.

Current research interests include the molecular dynamic simulation in explicit water to determine protein structure.

Collagen II: Collagen II is the major component of cartilage and bone growth plates. Mutation in the COL2A gene coding for collagen II are known to result in the skeletal disorders achondrogenesis, hypochongrogenesis, spondylepiphiseal dysplasia (SEDc), Sticklers Syndrome, Kniest Syndrome and early onset osteoarthritis and osteoporosis. Of particular interest are the set of glycine to serine mutations that are known to result in the genetic disorders achondrogenesis, hypochongrogenesis and SEDc. These represent increasing levels of severity from lethal to moderate, respectively. This is curious since the type of mutation (G to S) is the same in all cases. Therefore, the outcome must be related to the position of the mutation along collagen chain or the amino acid constituency in which the mutation finds itself.

Molecular dynamic simulation is particularly suited to study the affect of point mutations on collagen trimer stability of model native peptides. I am examining the changes in hydrogen bonding, dihedral angles and chain distance induced by the insertion of the mutation into the native sequence. In doing so, I hope to understand why the same mutation has such a diverse outcome depending on its location along the collagen trimer.

Collagen I – This project seeks to understand the nature of the binding between dental adhesives and collagen I in dentin using molecular dynamic simulation and docking. It is expected that the resulting information will be useful in developing new dental adhesive.

Aquaporin 0 – Aquaporin 0 (MIP26) is a transmembrane water pump found in several organs including the lens of the eye. Two human mutations E134G and T138 R (http://www.biochem.ucl.ac.uk/bsm/humgen/omim/154050/)  are known to result in congenital cataracts. These mutations are known to be located in the vicinity of the pore and their effect on the pore is under study.

 

Education:

Ph.D:  Physical Chemistry      1985    Rutgers University - Newark; NJ
M.S.: Physical Chemistry       1980    Rutgers University – Newark, NJ
B.S.:  Chemistry                     1973    Fairleigh Dickinson University - Teaneck 
Postdoctoral Training: -         1986-1989 - Rutgers University – Newark, NJ

 

Experience:

2002 -2004 Researcher (UMDNJ-RWJMS)
         Collagen Lab
         Computaing (Volunteer)
2001-2005  Fisher Scientific, Morris Plains –Consultant .
2000-2001 - “Building Hope-A Community Response”- a 501c organization – 1 year flood relief project. Executive Administrator
1999-2000 East Stroudsburg University-East Stroudburg, PA -Instructor-Chemistry
1996-1999  Ramapo College, Mahwah, NJ - Assistant Professor – Chemistry .
1994-1996 - Morris Area Science Alliance, Randolph, NJ - Executive Director
1990-1996 - County College Of Morris, Randolph, NJ -Adjunct Assistant/Associate Professor - Chemistry.
1978-1980 - Oakite Products, Inc., Berkeley Heights, NJ - Research Projects Manager
1977-1978 - Church & Dwight, Inc., Princeton, NJ - Research Chemist -
1973-1977 - Oxy-Metal Industries, Sel-Rex, Inc., Nutley, NJ - Chemist -

 

Oral Presentations:

2007 MARM Conference, Ursinus College, Collegeville, PA, May 16, 2007, Molecular Dynamic Approach to the Study of the Effect of Point Mutations on the Structure of Collagen.

 

Students:

The 59th Annual Research Conference of Student Affiliate Chapters, North Jersey

Section, Drew University, Madison, NJ. , April 27, 2007,

Megan Redd Molecular Dynamic Study Of The Structural Impact Of The Human G705S Point Mutation Collagen II Model Peptides   ( 3rd place)

Jennifer Zalk Molecular Dynamic Study Of The Structural Impact Of The Human G900S Point Mutation Collagen II Model Peptides

 

Poster Sessions:

2004 Molecular Biophysics Mini-symposium – Rutgers Cook Campus, New Brunswick, NJ – May 27, 2004- Gloria T. Anderle and John E. Kerrigan, UMDNJ-RWJMS, New Brunswick, NJ, Molecular Dynamics Study of the Consequences of a Gly Substitution Mutation on the Collagen Triple Helix.

2003 MARM Conference, Princeton University, Princeton, NJ – June 10, 2003-: Gloria T. Anderle and John E. Kerrigan, Dept. Pharmacology & Physiology, Robert Wood Johnson Medical School UMDNJ, Piscataway, NJ & Patricia N. Farnsworth, Dept. Pharmacology, UMDNJ-NJMD, Newark, NJ, Molecular Dynamics Study of a-A Crystallin Mini-chaperone and A-b Peptide Self-complementary Sequences

 

Students:

Megan Redd and Gloria T. Anderle, A Molecular Dynamic Simulation Study of the Effect of the G705S Point Mutation on the Structure of a Collagen II Peptide

1. 9th Annual Undergraduate Research Symposium and Student Award Night Hosted by: Hudson Bergen Chemical Society and FDU School of Natural Sciences: April 13, 2007:  

2. Becton College Scholars Research Day, Fairleigh Dickinson University, Madison, NJ., April 20, 2007  

3. 1st Annual Undergraduate Research Symposium at William Paterson University, April 21, 2007. (2nd Place Winner, Biochemistry)

Jennifer Zalk and Gloria Anderle,A Molecular Dynamic Simulation Study of the Effect of the G900S Point Mutation on the Structure of a Collagen II Peptide.

1. 9th Annual Undergraduate Research Symposium and Student Award Night Hosted by: Hudson Bergen Chemical Society and FDU School of Natural Sciences: April 13, 2007: 

2. Becton College Scholars Research Day, Fairleigh Dickinson University, Madison, NJ., April 20, 2007 

3. 1st Annual Undergraduate Research Symposium at William Paterson University, April 21, 2007. (2nd Place, Biochemistry)

Kristy Mullarkey, Stephen Yudin and Gloria Anderle, Chemistry Dept. E. Stroudberg University, E. Stroudsberg, PA,  Characterization of Zucchini Hypocotyl Plasma Membrane Vesicles., ESU Sigma Xi Research Forum – E. Stroudsburg, PA- Apr. 12, 2000

Laura Opdam and Gloria T. Anderle, Chemistry Dept. Ramapo College Mahwah, NJ, FTIR Study of the Interaction of Ethylene with Zucchini Hypocotyl Plasma Membranes

1. New York Chemistry Students’ Association 47th Annual Undergraduate Research Symposium – May 1, 1999 – College of Mt. St. Vincent, NYC, NY.

2. Hudson-Bergen Regional Sigma Xi Awards Dinner- Ramapo College, Mahwah, NJ, Apr. 23, 1999

Publications:

Michael A. Bryan, Joseph W. Brauner,  Gloria Anderle, Carol R. Flach, Barbara Brodsky, Richard Mendelsohn  FTIR Studies of Collagen Model Peptides: Complementary Experimental and Simulation Approaches to Conformation and Unfolding, (2007),J. Am. Chem. Soc., 129 (25), p7877 -7884,

J.Yang, GL Anderle, R. Mendelsohn,Effects of Cholesterol on the Interactions of CaATPase With POPE. An FTIR Study, (1990), Biochemica et Biophysica Acta, Vol. 1021, p27-32.

G. Anderle and R. Mendelsohn, Thermal Denaturation of Globular Proteins. FTIR Studies of Amide III Spectral Region. (1987), Biochemical Journal, Vol. 52, p69-74.

G. Anderle and R. Mendelsohn, Survey of Lipid-Protein Interactions of CaATPase, (1986), Biochemistry, Vol. 25, p2174-2179.

R. Mendelsohn R, G.Anderle, M. Jaworsky, HH Mantsch, RA Dluhy,. Fourier TransformInfrared Spectroscopic Studies of Lipid-Protein Interactions in Native and Reconstituted Sarcoplasmic Reticulum, (1984), Biochemica et Biophysica Acta, Vol. 775, p215-224.

L. M. Gierasch, J. E. Lacy, G. Anderle, R. Lalancette and R. Mendelsohn,Spectroscopic Studies of Hydrophobic Peptides in Membrane-Like Environments, (1983), Biopolymers, Vol. 22, p381 -385.

Paul Hemmes, Leslie Oppenheimer, Robert Rhinesmith, Gloria Anderle, David  Saar and Frank Jordan, Ultrasonic Relaxation and Proton NMR Evidence Demonstrating that Urea Destacks 6-Methylpurine Aggregates, (1980), Journal of Physical Chemistry, Vol. 84, p911-913.

 

Professional Societies: 

American Chemical Society
Sigma Xi
Society for Applied Spectroscopy – NY Chapter
Coblenz Society
 

Contact:

Dr. Gloria Anderle
Department Chair
Tel: (973) 443-8778
Fax: (973) 443-8795
ganderle@fdu.edu

Department of Chemistry and Pharmaceutical Science
Fairleigh Dickinson University
285 Madison Ave - M-SB1-01
Madison, NJ 07940


Fairleigh Dickinson University Mansion
Office Location
Science Building
Room 22