Dr. Patricia Melloy
Courses Taught at FDU
Cell Biology, Cell Biology of Cancer, Developmental Biology, Cell Signaling, Biology Seminar, Current Topics in Biology, Histology
The focus of research in my laboratory is the cell biology of the budding yeast Saccharomyces cerevisiae (also known as brewer’s or baker’s yeast). Many cellular processes occur in both yeast and human cells, and are controlled by similar genes. One advantage of budding yeast as a model system is the speed and ease of creating genetic mutants to study different cellular events. We can study the genes regulating cellular processes in yeast, and then apply our knowledge of gene functions and genetic interactions to studies of human disease.
We are specifically interested in the regulation of nuclear envelope membrane dynamics during cell division, as well as the changes in the nuclear envelope taking place during other stages of the yeast life cycle, such as yeast mating. We are working to identify genes involved in controlling nuclear envelope fission, and to learn how nuclear envelope fission is coordinated with other cell division events.
Postdoctoral training, Princeton University, Molecular Biology
Ph. D., University of Pennsylvania, Cell and Molecular Biology
M.S., Villanova University, Biology
B. S., Loyola University Maryland (formerly Loyola College), Biology
Melloy, P.G. 2014. Using an international p53 mutation database as a foundation for an online laboratory in an upper level undergraduate biology class. Biochemistry and Molecular Biology Education. published online 14 Nov 2014
Melloy, P., Shen, S., White, E. and M. D. Rose. 2009. Distinct roles for key karyogamy proteins during yeast nuclear fusion. Molecular Biology of the Cell 20: 3773-3782.
Melloy, P., Shen, S., White, E., McIntosh, J.R., and M.D. Rose. 2007. Nuclear fusion during yeast mating occurs by a three-step pathway. Journal of Cell Biology 179: 659-670.
Melloy, P.G., Kusinerczyk, M.K., Lo, C.W. and M. E. Desmond. 2005. The overexpression of connexin43 alters the mutant phenotype of mid-gestational wnt-1 null mice resulting in recovery of the midbrain and cerebellum. Anatomical Record 283A: 224-238.
Melloy, P.G. and S.L. Holloway. 2004. Changes in the localization of the Saccharomyces cerevisiae anaphase-promoting complex upon microtubule depolymerization and spindle checkpoint activation. Genetics 167: 1079-1094.
Meyn III, M.A., Melloy, P.G., Li, J., and S.L. Holloway. 2002. The destruction box of the cyclin Clb2p binds the anaphase-promoting complex/cyclosome subunit Cdc23p. Archives of Biochemistry and Biophysics 407: 189-195.
Melloy, P.G., Ewart, J.L., Cohen, M.F., Desmond, M.E., Kuehn, M.R., and C.W. Lo. 1998. No turning, a mouse mutation causing left-right and axial patterning defects. Developmental Biology 193: 77-89.
Selected Conference Presentations:
Van, Eeuwen, T*., Luginsland, J., Melloy, P. and G. Anderle. 2014. Homology modeling and functional analysis of the mitotic checkpoint complex in budding yeast. American Society for Cell Biology Meeting. December 6-11. Philadelphia, PA. *Honors thesis student
Chevinsky, S., Bangug, L. Quigley, E*. and P. Melloy. 2014. Okp1-GFP localization in Saccharomyces cerevisiae during anaphase. 8th Annual William Paterson University Undergraduate Research Symposium. Wayne, New Jersey. April 12. *Honors Thesis Student.
Giyanani, N*. and P. Melloy. 2014. Localization of mitochondria in septin mutants in Saccharomyces cerevisiae. 8th Annual William Paterson University Undergraduate Research Symposium. Wayne, New Jersey. April 12. *Honors Thesis Student.
Victer, R. S. and P. Melloy. 2012. The trajectory of innovation in the AIDS segment. Global Innovation and Knowledge Academy (GIKA). Valencia, Spain . July 10-12. (Presented by R. Victer).
Romanyshyn, K., Tess, A. and P. Melloy. 2012. Saccharomyces cerevisiae septin stability and non-permissive temperature and its effect on nuclear fission. 6th Annual William Paterson University Undergraduate Research Symposium. Wayne, New Jersey. April 14.
Garbin, M.*, Quigley, E*. and P. Melloy. 2012. Studying the effects of CDC23 mutants on the localization of the anaphase-promoting complex activator CDC20 in Saccharomyces cerevisiae. 6th Annual William Paterson University Undergraduate Research Symposium. Wayne, New Jersey. April 14. *Honors Thesis Project.
Melloy, P. 2009. Incorporating Fluorescence Microscopy into Both the Cell Biology Laboratory Class Experience and Undergraduate Research with Students in a Science Teacher Preparation Program. American Society for Cell Biology Meeting. San Diego, CA. December 5-9.
Aiello, N.* and P. Melloy 2009. Characterizing the Anaphase-Promoting Complex: Protein-Protein Interactions and localization of Apc5p, Cdc23p, and Cdc20p in Budding Yeast. Metropolitan Association of College and University Biologists (MACUB) 42nd annual conference at Kingsborough Community College, October 24, 2009. *Honors thesis project
Patel, P.*, Melloy, P., and M. Rose. 2008. Nuclear envelope fission in Saccharomyces cerevisiae. Metropolitan Association of College and University Biologists (MACUB) 41st annual conference at Montclair State University, November 1, 2008. *Honors thesis project
Melloy, P., Shen, S., White, E., McIntosh, J. R., and M. D. Rose. 2007. Distinct roles for key karyogamy proteins in nuclear fusion. Yeast Cell Biology. Aug. 15-19. Cold Spring Harbor, NY.
Melloy, P., Shen, S., White, E., Winey, M., McIntosh, J.R., and M. Rose. 2006. Following the steps of nuclear envelope fusion in budding yeast. Yeast Genetics and Molecular Biology (Genetics Society of America). July 25-30. Princeton, NJ.
Melloy, P. and M. Rose. 2006. Following nuclear envelope fission in budding yeast. Yeast Genetics and Molecular Biology (Genetics Society of America). July 25-30. Princeton, NJ.
National Science Foundation Major Research Instrumentation Award, 2007.
Phone: (973) 443-8757
Email: pmelloy @ fdu.edu
Office: Science 14